The subject of this study is the French painter Germain Fabius Brest (1823-1900), who came to Istanbul in the mid-19th century and took part in the art scene of the city for more than three years, and his works on Istanbul. Germain Fabius Brest started his artistic career with the education he received at the Marseille Fine Arts School, and produced works that reflect the characteristics of the Romanticism movement in landscape painting with the lessons he took from the artists of the Barbizon School. The artist's trip to Istanbul in 1855 was a turning point in his art life, and he was considered among the Orientalist painters of the period, especially with his Istanbul-themed works. It is known that Germain Fabius Brest, who, as a highly productive painter, reflected the images of the Ottoman city on his canvases for many years, has many works on Istanbul. In this study, which focuses on a few selected examples from the works in question, it is aimed to evaluate the composition and the subjects that Brest created in his works depicting Istanbul in the context of 19th century Orientalist painting style.