This article aims to examine human–machine co-creativity within the framework of Gilles Deleuze’s concepts of Difference and Repetition. The increasingly active role of artificial intelligence and computational systems in artistic production necessitates a rethinking of creativity, subjectivity, and originality. The study investigates how the creative relationship between humans and machines operates not merely as a form of tool use or imitation, but as a dynamic and distributed creative process in which difference is produced. Deleuze’s approach, which conceives repetition as a productive principle based on differentiation rather than identity, provides a theoretical ground for understanding human–machine co-creative processes. By addressing the interaction between algorithmic repetition, variation, and human intervention, the article discusses, through selected examples, how these processes generate distinctive differences in artistic outputs. In this context, the study conceptualizes human–machine co-creativity as a field of continuous becoming and differentiation, rather than as the reproduction of representation.